Role overview
Alexion is seeking a Medical Ethics Manager to support its UK & Ireland Rare Disease business. As a Nominated Signatory and trusted cross-functional partner, you will help teams deliver patient-centred, scientifically sound activities in line with applicable Codes, legislation and company standards. You will provide pragmatic, evidence-based advice and strengthen review processes, capability and insight, including the responsible use of approved AI-enabled tools with appropriate human oversight.
Key responsibilities
- Review and approve agreed promotional and non-promotional materials, activities and meetings as a Nominated Signatory, applying ABPI/IPHA Codes, relevant legislation and Alexion standards.
- Advise cross-functional partners on medical ethics and compliance questions; elevate novel, high-risk or precedent-setting matters appropriately.
- Maintain review procedures, checklists and operational controls, and support training, coaching, signatory validation and continuous improvement.
- Use approved digital and AI-enabled tools to improve review quality, consistency, insight and turnaround; validate outputs and protect confidential, personal and proprietary information.
- Monitor review data and recurring themes, identify workflow and training improvements, and provide updates and delivery-risk escalations to the Medical Ethics Lead.
Candidate profile
Essential: Registered physician or pharmacist eligible to act as a Nominated Signatory; experience in Medical Affairs, medical review, signatory work or pharmaceutical compliance; strong working knowledge of the ABPI Code and relevant UK requirements; clear communication, sound ethical judgement and effective cross-functional partnering. Candidates should be comfortable using approved digital tools responsibly and handling confidential information with discretion.
Desirable: Rare-disease or complex patient-pathway experience; knowledge of the IPHA Code; experience with AI-enabled review or workflow improvement; and coaching, training or change-adoption experience.
Role details and application
- Employer: AstraZeneca / Alexion (Alexion, AstraZeneca Rare Disease)
- Location: St Pancras, London
- Type: Full-time
- Working pattern: Average expectation of at least three days per week in the office; individual flexibility is considered
- Salary: Competitive, plus excellent benefits
- Closing date: 10 November 2026
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