Senior Scientist I / II – Translational Immuno‑Oncology Research

Overview

In this role you bridge exploratory cancer immunology research to early clinical development within the Oncology Translational Research team. You will lead hands-on biomarker-focused assays to inform decision-making in hematologic malignancies and solid tumors, collaborating cross-functionally to advance therapeutic concepts. Your work translates biology into robust experiments, contributing to publications and technical reports. The role combines scientific depth with practical impact in a fast-paced, onsite Cambridge setting.

Pay / Benefits

• flexible and hybrid working options
• minimum 14 weeks paid parental leave
• comprehensive health, life and disability benefits
• retirement plans with company match
• performance-based bonus possible
• equity consideration and time-off package

Responsibilities

• Design and optimize multiparameter/spectral flow cytometry and related cell-based assays to profile immune, stromal, and tumor populations across hematologic malignancies and solid tumors
• Perform ex vivo studies using human primary cells, tumor cell lines, and patient-derived samples, including complex co-cultures, with sterile technique
• Develop readouts for proliferation, viability, apoptosis, differentiation, cytokine signaling, and target engagement to support mechanism of action analyses
• Analyze data with appropriate statistics and visualization tools; communicate interpretations and next steps to project teams
• Plan and execute experiments aligned with project strategy, manage priorities, and deliver reproducible data within timelines
• Maintain accurate ELN records and ensure traceability of methods, samples, analyses, and conclusions
• Introduce and qualify new lab methods that improve decisions, throughput, or data quality
• Contribute to publications, train colleagues, and collaborate across functional teams

Key requirements

• Bachelor’s degree with 5+ years (Scientist I) or 7+ years (Scientist II) of relevant experience, or Master’s degree with 3+ years (I) or 5+ years (II)
• Advanced hands-on experience with multiparameter or spectral flow cytometry (panel design, sample prep, instrument operation, QC, analysis)
• Experience with primary human cell culture and immune-cell or tumor-biology assays, including complex co-cultures and patient-derived material
• Intracellular cytokine staining and multiplex cytokine assays (e.g., MSD) to quantify pharmacodynamic responses
• Strong quantitative data analysis and presentation skills (GraphPad Prism, Spotfire) with ability to produce decision-ready figures
• Ability to independently design and execute rigorous experiments and translate results into actionable recommendations
• Excellent organization, collaboration, and written/oral communication; meticulous ELN documentation
• Desirable: experience with IncuCyte or real-time cell analysis; prior biotech/pharma industry experience

• collaboration
• curious mindset
• detail-oriented
• multiparameter/spectral flow cytometry
• primary human cell culture
• intracellular cytokine staining

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