Senior Director Observational Research

Overview

As Senior Director of Observational Research, you lead global clinical operations strategy for observational studies and real-world evidence at Amgen. You shape the function, align delivery with product development, and drive compliant, high-quality evidence generation. You partner with cross-functional teams to advance portfolio priorities and transform observational methods into scalable operations. This role offers impact across patient outcomes and strategic evidence agendas in a collaborative, science-driven culture.

Pay / Benefits

• competitive benefits
• Total Rewards Plans

Responsibilities

• Lead global strategy, planning, and execution for the Observational Research portfolio, aligning with product development goals
• Translate innovative evidence-generation strategies into scalable operational delivery models (observational research and pragmatic trials)
• Oversee portfolio governance, budgets, resource allocation, vendor strategies, risk management, and performance
• Foster strategic partnerships with Product Teams, CfOR, GDO, and cross-functional stakeholders to ensure portfolio success
• Build and develop the Observational Research function, including workforce planning and talent development
• Drive quality, compliance, and inspection readiness through standardized processes and continuous improvement
• Represent the function in senior leadership forums to influence strategic decisions and future evidence capabilities

Key requirements

• Degree educated
• Extensive experience in clinical research, clinical operations, and/or real-world evidence, with biopharma background
• Proven leadership of global clinical operations and complex programs, especially observational research and pragmatic trials
• Strong business acumen and ability to translate objectives into actionable plans
• People leadership experience with global teams and talent development
• Solid understanding of global clinical development, GCP, regulatory and quality standards
• Experience managing portfolio planning, budgets, governance, and external partnerships including CROs
• Proven track record of driving transformation, innovation, and continuous improvement
• Strong executive presence, communication, and influencing skills in global matrix organizations
• Strategic decision-making and problem-solving with focus on risk management and portfolio delivery

• leadership
• strategic thinking
• communication
• observational research
• real-world evidence generation
• pragmatic clinical trials

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