Senior Scientist I/II- Translational Medicine- PKS, ADME (dual level posting*)

Overview

In this role you will support discovery and development by designing, executing, and interpreting in vitro ADME assays while expanding lab automation for high-quality data. You will collaborate with cross-functional PK teams to guide compound optimization and decision-making, contributing to novel methodologies and automated end-to-end workflows. The position combines hands-on ADME work with AI-enabled analytics to scale throughput and standardize assay operations, within a mission-driven biotech context.

Pay / Benefits

• comprehensive benefits package
• 401(k) with company contribution and match
• performance-based cash incentive
• eligibility for annual equity awards
• generous time off package

Responsibilities

• Plan, execute and report ADME assays (metabolic stability, permeability) to support PK strategies
• Interpret in vitro ADME data to inform early discovery and optimization decisions
• Contribute to new ADME methodologies and expand assay capabilities
• Advance automation strategies (liquid handling, miniaturization, multiplexing) to increase capacity and reduce manual work
• Execute and contribute to automated end-to-end ADME workflows with AI-enabled analytics
• Develop methods for bio-analysis using LCMS-MS, HRMS, and ICP-MS
• Troubleshoot lab instrumentation and automation platforms
• Manage study timelines, objectives and budgets and track progress
• Communicate data, strategy and results to project teams
• Contribute to internal ADME reports and regulatory documents (IND, IMPD, NDA)
• Participate in cross-departmental teams and initiatives
• Complete organizational trainings and adhere to SOPs, quality, and HSE guidelines

Key requirements

• BSc or MSc with relevant ADME/DMPK experience
• BSc: 7+ years; MSc: 4+ years in ADME/DMPK
• Experience in drug discovery or development laboratory or CRO/Pharma/Biotech desirable
• Experience in metabolic stability and permeability assays; cell culture experience a plus
• Experience with automation integrated with AI-enabled analytics is highly desirable
• Knowledge of related disciplines (bioanalytical, toxicology, biomarkers) in drug discovery
• Ability to work in a cross-functional, dynamic team; strong organizational and problem-solving skills
• Fluent oral and written English

• collaboration
• critical thinking
• strong communication
• ADME/DMPK
• metabolic stability assays
• permeability assays

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